Fibrinogen and Blood Viscosity

Oct 13, 2025 by leolavanderia.com.br 84 views

The Relationship Between Fibrinogen Levels and the Results of the Transcranial Doppler (TCD) Examination in Patients with Acute Ischemic Stroke

Introduction

Acute ischemic stroke is a condition that occurs when there is a blockage in the blood vessels supplying blood to the brain, leading to a decrease in blood flow and oxygen supply to the brain tissue. This condition can cause significant damage to the brain and can be life-threatening if not treated promptly. One of the key factors that contribute to the development of acute ischemic stroke is the increase in blood viscosity, which can be caused by high levels of fibrinogen in the blood.

Fibrinogen and Blood Viscosity

Fibrinogen is a protein produced by the liver that plays a crucial role in blood clotting. When fibrinogen levels are high, it can increase blood viscosity, making it more difficult for blood to flow through the blood vessels. This can lead to a decrease in blood flow and oxygen supply to the brain, which can cause damage to the brain tissue. In patients with acute ischemic stroke, high levels of fibrinogen have been associated with a poor prognosis and increased risk of complications.

Transcranial Doppler (TCD) Examination

Transcranial Doppler (TCD) examination is a non-invasive method used to evaluate blood flow in the cerebrovascular system. It uses high-frequency sound waves to measure the velocity of blood flow in the blood vessels of the brain. TCD examination is a useful tool for diagnosing and monitoring acute ischemic stroke, as it can provide information on the severity of blood flow restriction and the presence of any blockages in the blood vessels.

The Relationship Between Fibrinogen Levels and TCD Examination Results

Results

The results of the study showed that fibrinogen levels in the stroke group (549.16 ± 104.84 mg/ml) were significantly higher than the control group (385.64 ± 16.80 mg/ml) with a value of P = 0.00. On TCD examination, there were significant differences in the mean velocity, peak velocity, and end diastolic velocity between stroke and control groups, both in MCA and ICA. However, the results of the Pearson correlation analysis showed that there was no significant relationship between fibrinogen levels and the results of TCD examinations in the stroke group, both in MCA and ICA (P> 0.05).

Conclusion

This study provides important information about the role of fibrinogen in acute ischemic stroke, but further research needs to be carried out to clarify the relationship between fibrinogen levels and TCD examination results. The study shows a significant difference between fibrinogen levels and the results of TCD examinations (Mean Velocity, Peak Velocity, End Diastolic Velocity) in acute ischemic stroke groups and control groups. However, no significant relationship was found between fibrinogen levels and the results of TCD examinations in the stroke group.

Implications

The findings of this study have implications for the diagnosis and management of acute ischemic stroke. The study suggests that high levels of fibrinogen may be associated with a poor prognosis and increased risk of complications in patients with acute ischemic stroke. Therefore, monitoring fibrinogen levels and TCD examination results may be useful in predicting the outcome of patients with acute ischemic stroke.

Limitations

This study has several limitations that need to be addressed in future research. The study involved a small sample size, which may limit the generalizability of the findings. Additionally, the study did not control for other factors that may influence the relationship between fibrinogen levels and TCD examination results.

Future Research Directions

Future research should aim to clarify the relationship between fibrinogen levels and TCD examination results in patients with acute ischemic stroke. This can be achieved by conducting larger-scale studies that involve more participants and controlling for other factors that may influence the relationship between fibrinogen levels and TCD examination results.

Keywords

Fibrinogen
Transcranial Doppler
Acute Ischemic Stroke

References

[List of references cited in the study]

Appendix

[Appendix containing additional information or data that is not included in the main text]

Abstract

This study aimed to analyze the relationship between fibrinogen levels and the results of TCD examination in patients with acute ischemic stroke. The study involved 24 stroke patients and 25 controls, and data collection was carried out during the period July 2012 to June 2013. The results showed that fibrinogen levels in the stroke group were significantly higher than the control group, but there was no significant relationship between fibrinogen levels and the results of TCD examinations in the stroke group. The study provides important information about the role of fibrinogen in acute ischemic stroke, but further research needs to be carried out to clarify the relationship between fibrinogen levels and TCD examination results.
Frequently Asked Questions (FAQs) About the Relationship Between Fibrinogen Levels and TCD Examination Results in Acute Ischemic Stroke

Q: What is fibrinogen and how does it relate to acute ischemic stroke?

A: Fibrinogen is a protein produced by the liver that plays a crucial role in blood clotting. High levels of fibrinogen can increase blood viscosity, making it more difficult for blood to flow through the blood vessels. This can lead to a decrease in blood flow and oxygen supply to the brain, which can cause damage to the brain tissue.

Q: What is a TCD examination and how is it used in diagnosing acute ischemic stroke?

A: A TCD examination is a non-invasive method used to evaluate blood flow in the cerebrovascular system. It uses high-frequency sound waves to measure the velocity of blood flow in the blood vessels of the brain. TCD examination is a useful tool for diagnosing and monitoring acute ischemic stroke, as it can provide information on the severity of blood flow restriction and the presence of any blockages in the blood vessels.

Q: What were the main findings of the study on the relationship between fibrinogen levels and TCD examination results in acute ischemic stroke?

Q: What are the implications of the study's findings for the diagnosis and management of acute ischemic stroke?

A: The study's findings suggest that high levels of fibrinogen may be associated with a poor prognosis and increased risk of complications in patients with acute ischemic stroke. Therefore, monitoring fibrinogen levels and TCD examination results may be useful in predicting the outcome of patients with acute ischemic stroke.

Q: What are the limitations of the study and what future research directions are needed?

A: The study has several limitations, including a small sample size and the lack of control for other factors that may influence the relationship between fibrinogen levels and TCD examination results. Future research should aim to clarify the relationship between fibrinogen levels and TCD examination results in patients with acute ischemic stroke by conducting larger-scale studies that involve more participants and controlling for other factors.

Q: What are the potential benefits of monitoring fibrinogen levels and TCD examination results in patients with acute ischemic stroke?

A: Monitoring fibrinogen levels and TCD examination results may help to predict the outcome of patients with acute ischemic stroke and identify those who are at high risk of complications. This may enable healthcare providers to provide more targeted and effective treatment, which can improve patient outcomes.

Q: Can you summarize the main points of the study and its implications for the diagnosis and management of acute ischemic stroke?

A: The study found that fibrinogen levels in the stroke group were significantly higher than the control group, but there was no significant relationship between fibrinogen levels and the results of TCD examinations in the stroke group. The study's findings suggest that high levels of fibrinogen may be associated with a poor prognosis and increased risk of complications in patients with acute ischemic stroke. Therefore, monitoring fibrinogen levels and TCD examination results may be useful in predicting the outcome of patients with acute ischemic stroke.

Q: What are the next steps for researchers and healthcare providers in understanding the relationship between fibrinogen levels and TCD examination results in acute ischemic stroke?

A: Future research should aim to clarify the relationship between fibrinogen levels and TCD examination results in patients with acute ischemic stroke by conducting larger-scale studies that involve more participants and controlling for other factors. Healthcare providers should also consider monitoring fibrinogen levels and TCD examination results in patients with acute ischemic stroke to predict the outcome and identify those who are at high risk of complications.

Q: Can you provide any additional information or resources for readers who want to learn more about the relationship between fibrinogen levels and TCD examination results in acute ischemic stroke?

A: Yes, readers can find additional information and resources on the topic by searching online or consulting with a healthcare provider. Some recommended resources include the American Heart Association, the National Institute of Neurological Disorders and Stroke, and the American Stroke Association.